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There is still no clear explanation for why this condition develops, but it was hypothesized that patients who already have risk factors for pancreatitis have a greater chance of developing the disease

However, this does not prove that every symptom during weight loss is caused by toxicant mobilization, and current evidence has not established a unique GLP-1-related toxin release syndrome. Symptoms during GLP-1 treatment are more often explained by recognized medication effects, reduced food or fluid intake, dehydration, constipation, nutrient insufficiency, blood sugar changes, or gallbladder complications

Congenital hyperinsulinism is a heterogeneous condition in regards to genotype and phenotype

This strategy may improve long-term tolerability, however patients may be unable to fully stop treatment